Iron(III) Chloride–Promoted, Solvent‐Free, Facile, and Efficient Friedländer Synthesis of Quinolines

Abstract

A mild, efficient, and solvent‐free version of Friedländer annulation of 2‐amino ketones and α‐methylene carbonyl compounds for the synthesis of polysubstituted quinolines using a catalytic amount of commercially available iron(III) chloride at room temperature in excellent yields is described.

Keywords:

• 2‐amino ketones
• Friedländer synthesis
• iron(III) chloride
• α‐methylene carbonyl compounds
• quinolines

Acknowledgment

The authors thank the Council of Scientific and Industrial Research, New Delhi, India, for financial support.