Synthesis of Z‐N‐Alkenylformamides

Abstract

Commercially available difluorinated benzaldehyde was converted to the Z‐N‐alkenylformamides via Horner–Emmons olefination and Curtius rearrangement, followed by reduction with tri‐tert‐butoxy‐aluminohydride.

Keywords:

• Z‐N‐alkenylformamides (enamides)
• Curtius rearrangement
• Horner–Emmons olefination
• isocyante

Acknowledgments

We gratefully acknowledge support for this project by Consejo del Sistema Nacional de Educación Tecnológica (COSNET) 491–02‐P (2002). L. G. S. thanks Consejo Nacional de Ciencio y Tecnología (CONACyT) for the graduate fellowship.