Ecofriendly Synthesis of Novel Benzo-1,2,3-triazol-1-yl-(N-aryl)amidines and Their Conversion to Guanidines

Abstract

Novel benzo-1,2,3-triazol-1-yl-(N-aryl)amidines (1) have been conveniently synthesized by the solvent-free reaction between 1,2,3-benzotriazole and arylcyanamides under thermal/microwave conditions in good yield. The versatility of these compounds (1) as amidine transfer reagents has been established by their conversion to trisubstituted guanidines by reaction with amines under solventless, thermal/microwave conditions.

Keywords:

• Benzo-1,2,3-triazol-1-yl-(N-aryl)amidines
• guanidines
• microwave-assisted synthesis

ACKNOWLEDGMENTS

We are thankful to the University Grants Commission, New Delhi, for financial support and SAIF, Lucknow, and STEC-SAIF, CUSAT, Kochi, for elemental and spectral analyses.