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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 41, 2011 - Issue 15
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Original Articles

Novel and Efficient Method for the Synthesis of Racemic Fexofenadine

G. M. Raghavendra Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, India
,
K. B. Harsha Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, India
,
K. Vinaya Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, India
,
K. Mantelingu Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, IndiaCorrespondence[email protected]
&
K. S. Rangappa Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, IndiaCorrespondence[email protected] ; [email protected]
Pages 2296-2303 | Received 15 Dec 2009, Published online: 25 May 2011
 
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Abstract

Fexofenadine is a selective H1-histamine receptor antagonist, which is an attractive alternative treatment for allergy symptoms. An efficient and environmentally friendly synthetic approach for the preparation of fexofenadine was developed from commercially available cumene. The method involves the Friedel–Craft's reaction, substitution, reduction, bromination, and the Grignard reaction.

ACKNOWLEDGMENT

K. S. R. acknowledges BRNS Vide No. 2009/37/40/BRNS/2266, dated 23 November 2009.

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