Molecular Iodine–Catalyzed Mild and Effective Synthesis of β-Enaminones at Room Temperature

Abstract

Molecular iodine has been found to be an efficient and ecofriendly catalyst for the synthesis of β-enaminones from dimedone and amines at room temperature in the presence of acetonitrile within 60 min. The experimental procedure is simple, includes shorter reaction times, and results in excellent yields of the products.

Keywords:

• Acetonitrile
• amines
• dimedone
• β-enaminones
• molecular iodine

Notes

^a Isolated yields.

^b Reaction conditions: dimedone (5 mmol), aniline (5 mmol), and catalyst as shown in the table.

^a All reactions were performed using amine (5 mmol), dimedone (5 mmol), and iodine (0.1 mmol).

^b Isolated yield. All the compounds are known and physical properties agree with the reported values. Mass spectral data of all the products matches with the reported data.