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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 41, 2011 - Issue 17
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Original Articles

Simple, Three-Component, Highly Efficient Green Synthesis of Thiazolo[3,2-a]pyridine Derivatives Under Neat Conditions

Ramadan Ahmed Mekheimer Chemistry Department, Faculty of Science, Minia University, El-Minia, Egypt
,
Noha Mohamed Hilmy Women Students–Medical Studies & Sciences Sections, Chemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
,
Afaf Abdel Hameed Chemistry Department, Faculty of Science, Minia University, El-Minia, Egypt
,
Sawsan Dacrory Chemistry Department, Faculty of Science, Minia University, El-Minia, Egypt
&
Kamal Usef Sadek Chemistry Department, Faculty of Science, Minia University, El-Minia, EgyptCorrespondence[email protected]
Pages 2511-2516 | Received 15 Dec 2009, Published online: 29 Jun 2011
 
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Abstract

Green, highly efficient, three-component syntheses of thiazolo-[3,2-a]pyridine derivatives via reaction of malononitrile, aromatic aldehydes, and 2-mercaptoacetic acid with a catalytic amount of piperidine without solvent with molar ratios of 2:2:1.2 and 2:2.2:1, respectively, has been reported.

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