One-Pot Synthesis of 1-Phenylsulfonyl-2-aroylindoles

Abstract

Interaction of phenylsulfonyl-2-aminobenzaldehyde with 2-bromo-1-phenylethanones in the presence of K₂CO₃ followed by acid-catalyzed dehydration led to the formation of 1-phenylsulfonyl-2-aroylindoles.

GRAPHICAL ABSTRACT

Keywords:

• Alkylation
• 2-aroylindoles
• intramolecular aldol condensation
• phenylsulfonyl-2-aminobenzaldehyde

ACKNOWLEDGMENTS

We thank the University Grants Commission, New Delhi (32-194/2006/SR), for financial support. V. D. thanks the Council of Scientific and Industrial Research, New Delhi, for a senior research fellowship. The authors thank the Department of Science and Technology (DST-FIST) for a 300-MHz NMR facility.

Notes

^a Isolated yield.