Abstract
Trifluoroethanol is an efficient and recyclable medium in promoting one-pot, three-component condensation reactions of β-ketoesters, aldehydes, and urea (or thiourea) to afford the corresponding dihydropyrimidones in good yields. This protocol does not require the use of an acid or base catalyst.
GRAPHICAL ABSTRACT
ACKNOWLEDGMENTS
K. S. R. Acknowledges the University Grants Commission (phase 2) vide No. F. 540/10/2004-05 (SAP II) and the Department of Science and Technology–Funding for Infrastructure in Science and Technology program.
Notes
a Yields refer to those of pure isolated products characterized by IR, 1H NMR, LCMS, and elementary analysis.