Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 42, 2012 - Issue 3
402
Views
10
CrossRef citations to date
0
Altmetric
Original Articles

Trifluoroethanol as a Metal-Free, Homogeneous, and Recyclable Medium for the Efficient One-Pot Synthesis of Dihydropyrimidones

, , , , &
Pages 424-433 | Received 03 Aug 2010, Published online: 06 Oct 2011
 

Abstract

Trifluoroethanol is an efficient and recyclable medium in promoting one-pot, three-component condensation reactions of β-ketoesters, aldehydes, and urea (or thiourea) to afford the corresponding dihydropyrimidones in good yields. This protocol does not require the use of an acid or base catalyst.

GRAPHICAL ABSTRACT

ACKNOWLEDGMENTS

K. S. R. Acknowledges the University Grants Commission (phase 2) vide No. F. 540/10/2004-05 (SAP II) and the Department of Science and Technology–Funding for Infrastructure in Science and Technology program.

Notes

a Yields refer to those of pure isolated products characterized by IR, 1H NMR, LCMS, and elementary analysis.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 422.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.