Abstract
A four-step approach to perfluoro(2-(methoxymethoxy)ethyl vinyl ether) 5 from an acid-sensitive glycol ether 3 by liquid-phase direct fluorination (DF) has been described. The perfluoro precursor was achieved by control of the gradient increase of temperature (−20 °C to 15 °C) and addition of sodium fluoride. Improved workup with benzyl alcohol provided a convenient method for purification and a practical means for tracing the progress of fluorination.
GRAPHICAL ABSTRACT
ACKNOWLEDGMENTS
The authors thank Chenguang Research Foundation and the Analytical and Testing Center of Sichuan University for NMR analysis. Thanks are also extended to Guowei Yang and Fumin Hu for helpful discussions.
Notes
a Yield was based on methyl ester 4b obtained from addition of methanol to 4a and determined by the distilled fraction. Identity of each fraction was confirmed by 1H NMR characterization.