One-Pot Synthesis of 1,3,4-Thiadiazin-5-yl-chromen-2-one Derivatives via Three-Component Reaction

Abstract

An expeditious, one-pot reaction has been described for the preparation of 1,3,4-thiadiazin-5-yl-chromen-2-one derivatives. These compounds were synthesized by the reaction of 3-(2-bromoacetyl)coumarin with thiocarbohydrazide and various carbonyl compounds. The newly synthesized compounds were characterized by infrared, ¹H NMR, and mass spectra.

GRAPHICAL ABSTRACT

Keywords:

• 3-(2-Bromoacetyl)coumarin
• one-pot synthesis
• 1,3,4-thiadiazine
• thiocarbohydrazide

ACKNOWLEDGMENTS

The authors are thankful to the director, National Institute of Technology, Warangal, for providing facilities. One of the authors (C.H.V.S.R.) is thankful to the director for awarding an institute fellowship.