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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 42, 2012 - Issue 22
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Original Articles

Novel and Efficient Cyclization Procedure for the Synthesis of 2,5-Disubstituted-1,3,4-thiadiazoles Without Using Any Ring-Closing Reagents

, , &
Pages 3251-3260 | Received 09 Sep 2010, Published online: 18 Jul 2012
 

Abstract

A novel method for the synthesis of 2,5-disubstituted-1,3,4-thiadiazoles via direct ring closure of 1,6-disubstituted-2,5-dithioureas in dimethylformanide without using any ring-closing reagents has been accidentally discovered. Repeated and extended experiments confirmed that this is a very simple and efficient way to synthesize these kinds of fine chemicals. A series of novel 2,5-disubstituted-1,3,4-thiadiazoles have been synthesized via this method in good yields.

GRAPHICAL ABSTRACT

ACKNOWLEDGMENTS

This work was supported by the NSFC (Nos. 21064006, 21161018) and Gansu Natural Science Foundation (No. 1010RJZA018).

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