Multicomponent Synthesis of 1,2,3-Triazol-4-yl-methylthio-3-arylquinazolin-4(3H)-one Derivatives

Abstract

A novel, one-pot, three-component reaction for the synthesis of novel 1,2,3-triazol-4-yl-methylthio-3-arylquinazolin-4(3H)-one derivatives using the Huisgen 1,3-dipolar cycloaddition reaction of organic azides and in situ–prepared terminal alkynes in good to excellent yields is reported.

GRAPHICAL ABSTRACT

Keywords:

• Azide
• click chemistry
• propargyl bromide
• quinazolinone
• 1,2,3-triazole

ACKNOWLEDGMENT

We gratefully acknowledge financial support from the Research Council of Shahid Beheshti University and the Catalyst Center of Excellence (CCE).