One-Pot Synthesis of Hydroxybenzo[d]-oxazole-2-aliphatic Acid Derivatives by Meerwein's Reagent

Abstract

A general one-pot synthesis of hydroxylbenzo[d]oxazole-2-aliphatic acid esters and hydroxylbenzo[d]oxazole-2-amino acid esters was successfully achieved in good yield by using Meerwein's reagent.

GRAPHICAL ABSTRACT

Keywords:

• 2-Aminophenol
• benzo[d]oxazole
• Meerwein's reagent
• triethyloxonium tetrafluoroborate

ACKNOWLEDGMENT

We thank the National Comprehensive Technology Platforms for Innovative Drug Research and Development, 2009ZX09301-007, for the financial support.