Rapid and Efficient, Microwave-Assisted, Base-Catalyzed Synthesis of Some Novel 2,7-Disubstituted Pyrrolopyrimidinones

Abstract

A rapid synthesis of a series of new 5,6-dimethyl-7-phenyl-2-alkyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidinones and 5,6-dimethyl-7-benzyl-2-alkyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidinones was accomplished in good yields using microwave irradiation under base catalysis.

GRAPHICAL ABSTRACT

Keywords:

• Adenosine antagonist
• microwave-assisted synthesis
• pyrrolo-pyrimidinones

ACKNOWLEDGMENTS

R. P. M. thanks the Department of Science and Technology for providing a grant under Fast Track Fellowship for Young Scientists [SR/FTP/CS-59/2007] to carry out the research work. Authors thank H. M. Meshram and N. Nageswara Rao, Indian Institute of Chemical Technology, Hyderabad, for providing a CEM microwave synthesizer and for the help carrying out the reactions. Authors thank Shri K. V. Vishnu Raju, chairman, and Shri K. Srinivas Reddy, dean, Shri Vishnu Educational Society, and D. B. Raju, principal, Shri Vishnu College of Pharmacy, for providing infrastructural facilities to carry out the research work.