Novel Synthetic Route Toward Benzofuran-pyridine–Based Spirans

Abstract

A novel domino reaction of tetrahydrobenzofuro[3,2-c] or [2,3-c]pyridines with dimethylacetylene dicarboxylate (DMAD) or methyl propiolate (MP) resulted in the formation of spirobenzofuranpyridines in moderate yields. The spirobenzofuran derivatives reported may be considered analogs of the antifungal drug griseofulvin.

GRAPHICAL ABSTRACT

Keywords:

• Alkynes
• domino reaction
• griseofulvin analogs
• spirocompounds

ACKNOWLEDGMENT

This work was financially supported by the Russian Foundation for Basic research (grant #11-03-00164-a).