Synthesis of Aryl and Heteryl 1,3,4-Thiadiazinyl-phthalazine-1,4-dione Derivatives via a Multicomponent Approach

Abstract

An expeditious one-pot method has been developed for the synthesis of aryl, heteryl thiadiazinyl-phthalazine-1,4-diones via a multicomponent approach. Reaction of phenacyl bromides with thiocarbohydrazide and phthalic anhydride afforded corresponding aryl thiadiazinyl-phthalazine-1,4-diones. Similarly, reaction of 3-(2-bromoacetyl)coumarins with thiocarbohydrazide and phthalic anhydride afforded required heteryl thiadiazinyl-phthalazine-1,4-diones under the same reaction conditions in excellent yields. The structure of all the synthesized compounds was confirmed from their analytical and spectral data.

GRAPHICAL ABSTRACT

Keywords:

• 3-(2-Bromoacetyl)coumarins
• one-pot reaction
• phenacyl bromides
• phthalic anhydride
• thiocarbihydrazide

ACKNOWLEDGMENTS

The authors are thankful to the director, National Institute of Technology, Warangal, for providing facilities. One of the authors (C. H. V. S. R.) is thankful to M. H. R. D. for an institute fellowship.