Abstract
The addition/oxidative cyclization of alkynoates with 1,3-dicarbonyl compounds in the presence of Ag(I) leads to polysubstituted furans. The reaction corresponds to the construction of a furan fragment, which also provides a new way to form the C-O bond.
ACKNOWLEDGMENT
The authors thank the Guangdong University of Petrochemical Technology of China for financial support of this work.
Notes
a Reaction conditions: 1a (0.25 mmol), 2a (0.25 mmol), additive (1.2 equiv.), in 2 mL solvent at 80 °C for 5 h.
b Isolated yields.
c 100 °C.
d 120 °C.
a All the reactions are carried out using 1.0 mmol of 1, 1.0 mmol of 2, 1.2 equivalence of AgOAc in DMA (2.0 mL) at 120 °C for 3 h.
b Isolated yield.