One-Pot, Three-Component Synthesis of Pyrimido[4,5-b]quinoline-tetraone Derivatives in Water

Abstract

Novel pyrimido[4,5-b]quinoline-tetraones were prepared by the three-component reaction of 2-hydroxynaphthalene-1,4-dione, 6-amino-uracils, and aromatic aldehydes in aqueous media and catalyzed by p-toluenesulfonic acid. This protocol provides a simple one-step procedure with the advantages of easy workup, good yield of products, and environmental friendliness.

GRAPHICAL ABSTRACT

Keywords:

• Aldehyde
• 6-amino-uracils
• aqueous media
• 2-hydroxynaphthalene-1,4-dione
• pyrimido[4,5-b]quinoline-tetraones

Notes

Note. Reaction of 2-hydroxynaphthalene-1,4-dione, 4-chlorobezaldehyde, and 6-amino-uracil in the presence of p-TSA under reflux condition.

^a Yields refer to isolated products.

^a Yields refer to isolated products.