Design and Synthesis of Some New N-Phenylanthranilic Acids from Highly Sterically Hindered Anilines

Abstract

Some new N-phenylanthranilic acids were designed and synthesized from highly sterically hindered anilines in an efficient and convenient method using CuI as catalyst with microwave irradiation and conventional heating.

GRAPHICAL ABSTRACT

Keywords:

• Copper(I) iodide
• highly sterically hindered anilines
• microwave irradiation
• N-phenylanthranilic acids

ACKNOWLEDGMENTS

Funding from the Ministry of Science and Technology of China (No. 2010DFA32680) and the Fundamental Research Funds for the Central Universities (CDJRC10220010, CDJXS11232242) are gratefully acknowledged.

Notes

^a All the reactions were carried out with o-chlorobenzoic acid (4 mmol), 2,6-dimethylaniline (8 mmol), potassium carbonate (2 mmol), and solvent (3 mL) under microwave irradiation.

^b Yields refer to the isolated pure prouducts.

^a Yields refer to the isolated pure products.