CTACl as Catalyst for Four-Component, One-Pot Synthesis of Pyranopyrazole Derivatives in Aqueous Medium

Abstract

An environmentally benign four-component reaction in aqueous medium in the presence of cetyltrimethylammonium chloride (CTACl) has been developed for the synthesis of 6-amino-3-methyl-4-aryl-/1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile. The method presented is mild, environmentally friendly, inexpensive, and functionality tolerant and gives the products in good to excellent yields.

GRAPHICAL ABSTRACT

Keywords:

• CTACl catalysis
• four-component reaction
• pyrano[2,3-c]pyrazole derivatives
• water medium

ACKNOWLEDGMENT

The work was supported by the National Natural Science Foundation of China (No. 21162008).

Notes

^a Reaction carried out using compounds 1 (2.5 mmol), 2a (2.5 mmol), 3a (2.5 mmol), and 4 (2.5 mmol) in 10 ml water.

^b Isolated yield.

^a Isolated yields.