Reaction of Isatoic Anhydride, Amine, and N,N′-Dialkyl Carbodiimides Under Solvent-Free Conditions: New and Efficient Synthesis of 3-Alkyl-2-(alkylamino)quinazolin-4(3H)-ones

Abstract

Heating a mixture of isatoic anhydride, amines, and N,N′-dialkyl carbodiimides under solvent-free conditions provided novel 3-alkyl-2-(alkylamino)quinazolin-4(3H)-one derivatives for the first time. The products were obtained in moderate to good yields without formation of any by-products.

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GRAPHICAL ABSTRACT

Keywords:

• 3-Alkyl-2-(alkylamino)quinazolin-4(3H)-ones
• isatoic anhydride
• N,N′-dialkyl carbodiimides
• solvent-free

ACKNOWLEDGMENTS

This research was supported by grants from the research council of Tehran University of Medical Sciences and Iran National Science Foundation (INSF).

Notes

^a Isolated yields.