Recent Advances in Silyl Protection of Alcohols

Abstract

Silyl protection/deprotection of alcohols continues to play an important role in organic synthesis. New silyl groups and methods for their introduction and removal are constantly being developed and offer chemists a wider range of options in their use. In recent years, though, silyl protecting groups have been given expanded roles beyond their traditional use of temporarily rendering alcohols inactive. Merging the silyl protection/deprotection of alcohols with such modern methodologies as asymmetric techniques, fluorous chemistry, and nanoscience has added additional value to these temporary components of synthetic intermediates. This review covers developments in the use of silyl protecting groups of alcohols reported in the period 2007 to the end of 2011.

GRAPHICAL ABSTRACT

Keywords:

• Deprotection
• protecting group
• silyl ether