Synthesis of (+)-Septicine Using Intramolecular McMurry Coupling: A Chiron Approach

Abstract

Total synthesis of secophenanthroindolizidine alkaloid (+)-septicine 1 was accomplished using the McMurry coupling for the construction of indolizidine ring, using L-glutamicacid as chiral source.

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GRAPHICAL ABSTRACT

Keywords:

• Bromination
• McMurry coupling
• N-alkylation
• reduction
• umpolung

ACKNOWLEDGMENTS

The authors acknowledge Osmania University for providing the research facility and the Indian Institute of Chemical Technology for analytical data, and are also thankful to head of the department and vice chancellor of Osmania University for constant support and encouragement.