New Synthesis of (±)-Cherylline and Mono- and Dimethyl Ethers

Abstract

The synthesis of 4-aryl-1,2,3,4-tetrahydroisoquinolines is achieved via the ether rearrangement methodology. Subsequent reactions yielded cherylline and ether derivatives of amaryllidaceac alkaloids.

GRAPHICAL ABSTRACT

Keywords:

• Cherylline
• dimethyl cherylline
• ether rearrangement
• monomethyl cherylline

ACKNOWLEDGMENT

We thank Suven Life Sciences for the excellent analytical facilities and allowing us to publish these results.