Zeolite-Catalyzed Method for the Preparation of 2,3-Dihydroquinazolin-4(1H)-ones

Abstract

The reaction of isatoic anhydride, amines, and aldehydes in the presence of a microporous zeolite gave 2,3-dihydroquinazolin-4(1H)-one derivatives with good to excellent yield. The yield depends on the structure of the aldehyde and/or amine compound.

GRAPHICAL ABSTRACT

Keywords:

• Heterogeneous catalysis
• isatoic anhydride
• multicomponent reaction
• quinazolines
• zeolites

Notes

^a Crude product.

^b Recrystallized product.

^a Isolated yield.

^b In toluene.

^c Not determined.

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