Synthesis of Some Functionalized Peptomers via Ugi Four-Component Reaction

Abstract

This article describes the synthesis of new peptomers through a simple and efficient route using a one-pot Ugi four-component reaction. The synthesis started from either carboxylic acids or protected amino acids, primary amines, aldehydes, and isocyanides in anhydrous methanol and proceeded under stirring at room temperature. The reaction produced several functionalized peptomers in good yields (67–80%). These compounds are versatile multifunctional intermediates that can be further unprotected or functionalized to generate new molecules with numerous applications in the field of biomedicine.

GRAPHICAL ABSTRACT

Keywords:

• Diversity-oriented synthesis
• MCR
• multicomponent reaction
• one-pot reaction
• peptoid
• peptomer
• Ugi reaction

SUPPLEMENTARY MATERIAL

Full experimental details, characterization data for all compounds, and copies of the IR, ¹H NMR, and ¹³C NMR spectra for this article can be accessed on the publisher’s website.