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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 45, 2015 - Issue 16
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Original Articles

Synthesis of α-Ketoamides by Copper-Catalyzed Reactions of Phenylacetic Acids with N,N-Dialkylformamides

Lanping ZhangInstitute of Homogeneous Catalysis, College of Chemistry, Sichuan University, Chengdu, China
,
Junnan PuInstitute of Homogeneous Catalysis, College of Chemistry, Sichuan University, Chengdu, China
,
Jiayu RenInstitute of Homogeneous Catalysis, College of Chemistry, Sichuan University, Chengdu, China
,
Zhengkai LiInstitute of Homogeneous Catalysis, College of Chemistry, Sichuan University, Chengdu, China
,
Haifeng XiangInstitute of Homogeneous Catalysis, College of Chemistry, Sichuan University, Chengdu, China
&
Xiangge ZhouInstitute of Homogeneous Catalysis, College of Chemistry, Sichuan University, Chengdu, ChinaCorrespondence[email protected]
Pages 1848-1856 | Received 16 Mar 2015, Published online: 17 Jun 2015
 
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Abstract

A new synthetic approach for α-ketoamides was achieved by copper-catalyzed coupling reactions between N,N-dialkylformamides and phenylacetic acids. A variety of substrates were well tolerated to give yields of 46–87% (17 examples). A 13C-labeling experiment revealed that the carbonyl group of the products came from the phenylacetic acid.

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