Solid-Phase Benzoylation of Phenols and Alcohols in Microwave Reactor: An Ecofriendly Protocol

Abstract

An efficient solid-phase benzoylation of phenols and alcohols was developed under microwave irradiation. A stoichiometric amount of benzoyl chloride was sufficient to carry out the reaction. This benzoylation features short reaction time, good yields, and easy workup procedures. Furthermore, the scope of the reaction was extended to prepare 3,5-dinitrobenzoyl derivatives of alcohols.

GRAPHICAL ABSTRACT

Keywords:

• Benzoyl chloride
• benzoylation
• 3,5-dinitrobenzoyl chloride
• ecofriendly method
• microwave reactor
• solid-phase reaction

ACKNOWLEDGMENTS

The authors are thankful to Nandita Basu (Ghorai), director, and Santanu Tripathi, head of the Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata, for their cooperation. The authors are also thankful to Dr. Gautam Chattopadhyay, Ex-reader in Chemistry, Presidency College, Kolkata, for his insightful discussions.

SUPPLEMENTAL MATERIAL

Full experimental details, ¹H and ¹³C NMR spectra, and additional references for this article can be accessed on the publisher’s website.