Efficient Synthesis of Homoallylic Alcohols/Amines from Allyltributylstannane and Carbonyl Compounds/Imines Using Iodine as Catalyst Under Acetic Acid–Water Medium

Abstract

This paper describes a general method for the synthesis of homoallylic alcohols and amines by nucleophilic addition reaction of allyltributylstannane to carbonyl compounds and aldimines where iodine acts as a catalyst in H₂O/acetic acid (1:1) medium. Only 10 mol% of I₂ is required for various organic transformations. By using this process, various homoallylic alcohols and amines are produced in good to excellent yields.

GRAPHICAL ABSTRACT

Keywords:

• Aldimines
• allylation
• carbonyl compounds
• iodine