Solvent-Free Green Synthesis of Azines and Their Conversion to 2,5-Disubstituted-1,3,4-thiadiazoles

Abstract

A solvent-free, clean, and efficient method has been developed for the synthesis of 2,5-disubstituted-1,3,4-thiadiazoles via azines. This approach exploits the synthetic potential of clean reactions and offers many advantages such as excellent product yields, easy isolation of products, and ecofriendly benign reaction conditions. The newly synthesized compounds were analyzed by infrared, ¹H NMR, ¹³C NMR, and elemental analysis.

GRAPHICAL ABSTRACT

Keywords:

• Autoclave
• azine
• green synthesis
• solvent free
• 1,3,4-thiadiazole

SUPPLEMENTAL MATERIAL

Supplementary data (experimental details, NMR, MS, and elementary analysis) for this article can be accessed on the publisher’s website.