Synthesis of novel tetrahydroindeno[1,2-b]pyrrolidines via Ugi multicomponent and palladium-catalyzed aerobic oxidative cyclization

ABSTRACT

Novel tetrahydroindeno[1,2-b]pyrrolidines were conveniently prepared in moderate to good yields via a sequential Ugi multicomponent reaction or Staudinger/aza-Wittig/Ugi combination, followed by the palladium-catalyzed aerobic oxidative cyclization of the resulting Ugi adducts.

GRAPHICAL ABSTRACT

KEYWORDS:

• Oxidative cyclization
• tetrahydroindeno[1,2-b]pyrrolidines
• Ugi reaction