Isolation and conversion of penicillic acid to 6-iodo-α-pyran-2,5-dione: A key intermediate for the synthesis of pectinolide F

ABSTRACT

Penicillic acid was isolated from Aspergillus sclerotiorum and converted into 6-iodo-α-pyran-2,5-diones using iodolactonization, a key intermediate for the synthesis of pectinolide F. Structures of penicillic acid and its iodolactonized product were confirmed by using NMR experiments.

GRAPHICAL ABSTRACT

KEYWORDS:

• Aspergillus sclerotiorum
• iodolactonization
• 6-iodo-α-pyran-2,5-diones
• pectinolides
• penicillic acid

Acknowledgments

Authors are thankful to the director of IIIM Jammu for the encouragement.