ABSTRACT
β-Amino alcohols are versatile intermediates in the synthesis of various biologically potent compounds, which can also be achieved by ring opening of epoxides by amines. In the present review, focus has been placed on the ring opening of epoxides with amines under a variety of reaction parameters reported during 2011–2015. All the factors that resulted in excellent yields and high regioselectivity, are environmentally benign, and use mild conditions have been discussed in detail. In addition, the applications of these methods in the synthesis of biologically active compounds such as β-blockers have also been described.
GRAPHICAL ABSTRACT
Acknowledgment
The authors are thankful to Government College University Faisalabad and Higher Education Commission, Pakistan for providing facilities to carry out this work.