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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 46, 2016 - Issue 12
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Original Articles

Choline chloride as an efficient catalyst for the synthesis of styryl-pyrazoles

Hardesh K. MauryaMedicinal Chemistry Department, CSIR–Central Institute of Medicinal and Aromatic Plants, Lucknow, India
,
Kripa Shankar NainawatMedicinal Chemistry Department, CSIR–Central Institute of Medicinal and Aromatic Plants, Lucknow, India
&
Atul GuptaMedicinal Chemistry Department, CSIR–Central Institute of Medicinal and Aromatic Plants, Lucknow, IndiaCorrespondence[email protected]
Pages 1044-1051 | Received 07 Jan 2016, Published online: 17 Jun 2016
 
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ABSTRACT

An efficient and green methodology for syntheses of various styryl-pyrazoles (3) from the reaction of 2-(5-phenyl-1H-pyrazol-3-yl)acetonitriles (1) with substituted benzaldehydes (2) by the use of biodegradable, nonhazardous, naturally occurring, and inexpensive choline chloride and NaOH under an environmentally benign medium has been described.

GRAPHICAL ABSTRACT

Acknowledgment

The authors are thankful to the director of CSIR-CIMAP for his kind support.

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