Efficient and highly selective cyclization induced by Lewis acid to generate 2-hydroxyl-α-cyclogeraniol

ABSTRACT

A cyclization reaction of the hydroxyl-protected geraniol epoxide induced by the different Lewis acids to generate 2-hydroxyl-α-cyclogeraniol has been explored. Compared with the previous methods, this method enhances the production and selectivity of this reaction without the consumption of a large amount of solvent. Also, the coordination of the metal with two oxygen atoms of hydroxyl groups might be crucial for the reaction is first addressed.

GRAPHICAL ABSTRACT

KEYWORDS:

• concentration
• cyclization
• 2-Hydroxyl-α-cyclogeraniol
• Lewis acids
• protecting groups