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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 49, 2019 - Issue 3
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Synthetic Communications Reviews

Recent progress in the synthesis of diclofenac based NSAIDs analogs/derivatives

Freeha HafeezDepartment of Chemistry, Government College University, Faisalabad, Pakistan;
,
Ameer Fawad ZahoorDepartment of Chemistry, Government College University, Faisalabad, Pakistan; Correspondence[email protected] [email protected]
,
Sajjad AhmadDepartment of Chemistry, University of Engineering and Technology Lahore, Faisalabad Campus, Faisalabad, Pakistan
,
Matloob AhmadDepartment of Chemistry, Government College University, Faisalabad, Pakistan;
&
Sadia FaizDepartment of Chemistry, Government College University, Faisalabad, Pakistan;
Pages 325-350 | Received 30 Jan 2018, Published online: 10 Oct 2018
 
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Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are known for inhibition of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Diclofenac and its analogs, having phenylacetic acid moiety, are important NSAIDs. In this review article, various methodologies developed after 90 s for the synthesis of various analogs/derivatives of diclofenac sodium have been discussed and summarized.

Graphical Abstract

Acknowledgments

The authors are thankful to Government College University Faisalabad, UET Lahore FSD Campus and Higher Education Commission, Pakistan for providing facilities to carry out this work.

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