Iridium-catalyzed asymmetric hydrogenation of β-keto esters with new phenethylamine-derived tridentate P,N,N-ligands

Abstract

A new class of phenethylamine-derived tridentate P,N,N-ligands has been successfully developed. These ligands exhibited good performance in the Ir-catalyzed asymmetric hydrogenation of β-keto esters, affording the corresponding β-hydroxy esters in moderate to good enantioselectivities.

GRAPHICAL ABSTRACT

Keywords:

• Iridium
• P,N,N- ligands
• asymmetric hydrogenation
• β-keto esters

Acknowledgements

The authors are grateful for the financial support from the National Natural Science Foundation of China (Nos. 21403022, 21572226 and 21772196), Program of Star of Dalian Youth Science and Technology (No 2016RQ062), the Fundamental Research Funds for the Higher Education of Liaoning Province (2017J027), and Liaoning BaiQianWan Talents Program (201892153).