Rapid access to novel 2-alkylthiopyrimidine derivatives and attempt of their Tacrine analogs synthesis

Abstract

A variety of novel 2-alkylthiopyrimidines were synthesized through simple condensation of arylidenemalononitriles with different 2-alkylthiouronium halide derivatives catalyzed by anhydrous potassium carbonate (K₂CO₃). The reactions have been carried out under mild conditions in i-PrOH, and the products were obtained in moderate to good yields with a simple work-up method. Subsequently, some examples of these compounds have been converted into Tacrine analogs by applying the Friedländer reaction.

Keywords:

• Friedländer reaction
• pyrimidine-based heterocycles
• S-substituted thiopyrimidines
• Tacrine analogs

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Additional information

Funding

We thank “le Ministère de l’Enseignement Supérieur et de la Recherche Scientifique” (Algeria) for the financial supports.