Convenient stereoselective synthesis of some 3-aminosteroid scaffolds

Abstract

An efficient stereoselective synthesis 3α- and 3β-aminoandrostan-17-one and 3α-amino dehydroepiandrosten-17-one based on a Mitsunobu reaction has been developed, using azide as the ammonia equivalent. All the products were isolated in high yield.

Graphical Abstract

Keywords:

• Aminosteroids
• Staudinger reaction
• Mitsunobu reaction

Acknowledgment

The authors are grateful to and NORD University (Norway) and to the National Research Center (Egypt) for providing the facilities.

Disclosure statement

No potential conflict of interest was reported by the authors.