Synthesis of Barleriaquinones-I & II

Abstract

Synthesis of two naturally occurring anthraquinones, Barleriaquinone-I (BQ-I) and Barleriaquinone-II (BQ-II) is achieved from commercially available naphthalene-1,5-diol. The anthraquinone core is constructed by utilizing simultaneous Heck and cross coupling reaction as the key step.

Graphical Abstract

Keywords:

• Heck and cross coupling reaction
• Curtius reaction
• Suzuki coupling
• Barleriaquinone-I
• Barleriaquinone-II

Acknowledgements

The authors are thankful to GVK Biosciences Private Limited management for constant encouragement and providing facilities for accomplishing this research. Help from the analytical department for all spectroscopic analysis is highly appreciated. We are grateful to Dr. Sudhir Kumar Singh (President, Discovery and Development Services, GVK Biosciences) for his immense support and motivation. We are also thankful to AU, Visakhapatnam.