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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 49, 2019 - Issue 17
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Articles

Easy installation of 1,2,3-triazoles or iodo-1,2,3-triazoles onto indole-fused oxazinones via CuAAC-based MCR in the presence of 18-crown-6

A. MayooufiLaboratoire Synthèse et Isolement de Molécules BioActives (SIMBA), Faculté des Sciences et Techniques, Université de Tours, Tours, France; ;Laboratoire de Chimie Organique Structurale et Macromoléculaire, Département de Chimie, Faculté des Sciences de Tunis, Campus Universitaire El-Manar, Tunis, Tunisie
,
M. Romdhani-YounesLaboratoire de Chimie Organique Structurale et Macromoléculaire, Département de Chimie, Faculté des Sciences de Tunis, Campus Universitaire El-Manar, Tunis, Tunisie
,
Y. CarcenacLaboratoire Synthèse et Isolement de Molécules BioActives (SIMBA), Faculté des Sciences et Techniques, Université de Tours, Tours, France;
&
J. ThibonnetLaboratoire Synthèse et Isolement de Molécules BioActives (SIMBA), Faculté des Sciences et Techniques, Université de Tours, Tours, France; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-3817-210X
ORCID Icon
Pages 2168-2179 | Received 20 Feb 2019, Published online: 25 Jun 2019
 
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Abstract

An efficient protocol was developed to prepare indole-fused oxazinones using silver nitrate. The latter substrates were subjected to multicomponent reactions in the presence of 18-crown-6, which afforded diverse new heterocycles based on an indole-fused oxazinone-1,2,3-triazole scaffold.

GRAPHICAL ABSTRACT

Disclosure statement

No potential conflict of interest was reported by the authors.

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