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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 49, 2019 - Issue 17
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Articles

A concise synthesis of isoxazole-based side chain of Micafungin

Pallavi RaoDr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, Telangana, India
,
Ismail HussainDr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, Telangana, India
,
Venkataramanarao RaoDr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, Telangana, India
,
Saikat SenDr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, Telangana, India
&
Srinivas OrugantiDr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, Telangana, IndiaCorrespondence[email protected]
Pages 2180-2187 | Received 29 Jan 2019, Published online: 14 Jun 2019
 
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Abstract

A concise synthesis of key isoxazole-based side chain of Micafungin, an USFDA approved anti-fungal agent, has been delineated. The route design notably involves a one pot regioselective isoxazole construction from the corresponding aryl aldehyde and alkyne intermediates.

Graphical Abstract

Acknowledgements

We thank Dr. Reddy’s Institute of Life Sciences for its support. We thank Mahesh Tammineni for his help in synthesis of compound 12.

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