Abstract
Stereoselective synthesis of 16-membered macrocyclic core of marine natural product, Aspergillide D is described using linear strategy. The salient features of this synthetic study include the Sharpless asymmetric kinetic resolution followed by regioselective ring-opening reaction of corresponding epoxide to establish the stereo centers and ring-closing metathesis (RCM) by Grubbs'-II catalyst for the construction of macrocyclic ring.
Graphical Abstract
Acknowledgments
KSR thank UGC, India for the award of fellowship. All the authors thank Council of Scientific and Industrial Research (CSIR), New Delhi, India and CSIR-Indian Institute of Chemical Technology (IICT) for financial support.
IICT Communication No: IICT/Pubs./2019/273.