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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 51, 2021 - Issue 6
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Synthetic Communications Reviews

Magnetic nanocatalysts in A3-coupling reactions

Maryam Abedia Department of Chemical Engineering, Faculty of Imam Mohammad Bagher, Sari Branch, Technical and Vocational University (TVU), Mazandaran, Iran
,
Mojgan Hosseinib Department of Science, Islamshahr Branch, Islamic Azad University, Tehran, IranCorrespondence[email protected]
,
Arash Arabmarkadehc Biotechnology Group, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, Iran
&
Mosstafa Kazemid Young Researchers and Elite Club, Ilam Branch, Islamic Azad University, Ilam, IranCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4676-720X
ORCID Icon
Pages 835-855 | Received 04 Nov 2020, Published online: 27 Dec 2020
 
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Abstract

Propargylamines are a versatile class of amine molecules which find broad applications in numerous fields such as medicinal chemistry and drug discovery research. A3-coupling reaction of terminal alkynes, aldehydes and secondary amines is an efficient route for the synthesis of biologically active propargylamines. Over the last decade, the utilization of magnetic nanomaterials as heterogeneous reusable catalysts has received considerable attention in organic chemistry. In this review, we focus on the synthesis and versatile application of magnetically recoverable nanocatalysts in A3-coupling reactions.

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