N-Heterocyclic carbene palladium (II)-pyridine (NHC-Pd (II)-Py) complex catalyzed heck reactions

Abstract

A mild, efficient, and practical catalytic system for the synthesis of highly privileged stilbene pharmacophores is reported. This system uses N-heterocyclic carbene palladium (II) Pyridine (NHC-Pd (II)-Py) complex to catalyze the formation of carbon-carbon bonds between olefin derivatives and various bromide. This simple, gentle and user-friendly method can offer a variety of stilbene products in excellent yields under solvent-free condition. And its scale-up reaction has excellent yield and this system can be applied to industrial fields. The utility of this method is highlighted by its universality and modular synthesis of a series of bioactive molecules or important medical intermediates.

Graphical Abstract

KEYWARDS:

• NHC-Pd (II)-Py
• aromatic bromides
• olefins
• stilbene
• synthesis

Acknowledgments

Thanks to the Pharmaceutical Design and Synthesis Laboratory and the Key Laboratory of Biochemistry and Molecular Pharmacology of the School of Pharmacy of Chongqing Medical University for improving the experimental platform and facilities.

Additional information

Funding

The author is very grateful for the support of the Fundamental Research Fund of Chongqing Science and Technology Commission [No.X0221].