Design, synthesis, anti-cancer activity and in-silico studies of some novel 4,5-dihydroisoxazole-5-carboxamide derivatives

Abstract

A novel series of 4,5-dihydroisoxazole-5-carboxamide derivatives were designed, synthesized and evaluated for their anti-cancer activity against two different human cancer cell lines. Most of the synthesized compounds showed anti-cancer activity with IC₅₀ values ranging from 4.03 to 104.45 μM. Further, compounds 17h, 17i, 17e, and 18e were showed potent inhibitory activity against two cancer cell lines, with IC₅₀ values close to that of standard drug. It is important to note that compound 17h was more potent than the standard drug cisplatin with IC₅₀ values of 4.11 and 4.03 μM against Hela cell line and MCF-7 cell line respectively.

Graphical Abstract

Keywords:

• Anti-cancer activity
• docking studies
• isoxazoline
• synthesis

Acknowledgments

The authors would like to thank the management of AMRI Hyderabad research centre for giving an opportunity to carry out this research. The authors are also thankful to Sai innotech labs Pvt.Ltd. for providing synthesis facility.