Hygroline and pseudohygroline: Isolation, biological perspectives and synthesis

Abstract

Hygroline and pseudohygroline are naturally isolated pyrrolidine alkaloids and together exist in 4 different isomeric forms. They are 2-susbstituted pyrrolidine alkaloids with two chiral centers constituting 1, 3-amino alcohol unit. The present article discloses the isolation, biological significance and synthesis of these alkaloids. The various synthetic methods reported from 1943 to 2022 are briefly overviewed in this article. The different types of racemic synthesis and chiral synthesis are separately discussed.

Graphical Abstract

Keywords:

• Alkaloids
• asymmetric
• hallucination
• hygroline
• pseudohygroline

Correction Statement

This article has been corrected with minor changes. These changes do not impact the academic content of the article.

Acknowledgment

Dr. Chinmay Bhat and Dr. Basavaraj M B acknowledge Department of Collegiate Education (DCE) Bangalore, Government of Karnataka and India, along with University Grant Commission (UGC) for the financial assistance. Dr. Subrahmanaya Bhat thanks NMAM Institute of Technology, NITTE for the necessary support.