Synthetic strategies for thiazolopyridine derivatives

Abstract

Both thiazole and pyridine are well recognized heterocycles. The fusion of these two heterocycles results in thiazolopyridine ring system, which is the part of a large number of natural and synthetic products. Thiazolopyridine derivatives have significant biological and pharmaceutical importance such as anti-hypertensive, anti-oxidant, anti-fungal, anti-cancer, anti-mitotic, anti-microbial, anti-diabetic, analgesic, tuberculostatic and herbicidal. Various thiazolopyridine derivatives have found their applications in semiconductor and photographic materials. A large variety of synthetic methods have been employed for the facile synthesis of thiazolopyridine derivatives. This review article focuses on the synthesis of five isomeric thiazolopyridine systems.

Graphical Abstract

Keywords:

• Thiazolo[3
• 2-a]pyridines
• Thiazolo[4
• 5-b]pyridine
• Thiazolo[5
• 4-b]pyridine
• Thiazolo[5
• 4-c]pyridines
• Thiazolo[4
• 5-c]pyridine

Additional information

Funding

This work was supported by the Higher Education Commission of Pakistan, Government College University, Faisalabad, Pakistan.