Abstract
Novel fluorescent oxo-fluoro quinoline (E)-chalcone derivatives were synthesized using a new Aluminum Strontium Titanium Trioxide (Al-SrTiO3) solid catalyst. The Al-SrTiO3 catalyst was analyzed by spectroscopic techniques like Fourier Transform Infrared (FT-IR), X-Ray Powder Diffraction, absorption, Scanning Electron Microscopy, SEM-Mapping, Scanning Electron Microscopy with Energy Dispersive X-Ray Analysis and Raman spectroscopy. The novel precursors 2-(4-fluorophenoxy)quinoline-3-carbaldehyde derivatives (3a, 3b) were synthesized from 2-chloro-3-formyl quinoline and were subsequently used to synthesize the oxo-fluoro quinoline-based E-chalcones derivatives (5a–x). The chemical structure of 5a–x were investigated by FT-IR, 1H and 13C-NMR, 2D-NMR and high-resolution mass spectroscopy. Further, molecular docking studies on the hit compound 5t indicated hydrogen bond interaction with Bovine Serum Albumin at amino acids Arginine-194, 198 and 217 with bond lengths of 2.1, 2.2 and 2.2 Å, respectively. The calculated Gibbs free energy value was −5.84 kJ mol−1, while the experimental value of −27.82 kJ mol−1 was obtained from emission spectroscopy.
Graphical Abstract
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