Humic acid-catalyzed efficient synthesis of α-aminonitriles in water using potassium hexacyanoferrate (II) as a cyanide source

Abstract

A highly efficient, one-pot, three-component Strecker reaction for the synthesis of α-aminonitriles from carbonyl compounds, amines, and potassium hexacyanoferrate (II) (K₄[Fe(CN)₆]) in the presence of a catalytic amount of humic acid catalyst in water at room temperature has been developed. Advantages of this methodology are use of inexpensive, commercially available, environmentally friendly and reusable organocatalyst, environmentally benign and inexpensive cyanide source, simple experimental and work-up procedure, high yields, room temperature reaction, water as a green solvent and scaled-up synthesis.

Graphical Abstract

• Environmentally friendly, commercially available, inexpensive and reusable catalyst

• Environmentally friendly and inexpensive cyanide source

• High yields

• Simple operations and mild conditions

• Water as a green solvent

• Green synthesis

Keywords:

• α-aminonitriles
• humic acid
• organocatalyst
• potassium hexacyanoferrate(II)
• Strecker reaction

Additional information

Funding

The authors received the financial support from the National Natural Science Foundation of China (No. 51902004).